1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea
CAS No.:1346441-18-6
Molecular Formula:C₃₁H₂₅F₃N₈O₂
Molecular Weight:598.587
Hs Code.:

Synonyms:1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

There total 5 articles about 1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236202-88-2
C₁₂H₈F₃N₃O

: 1346441-48-2
C₁₉H₁₇N₅O

: 1346441-18-6
1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2011.09.042

Reference yield:

: 838-57-3
ethyl 4-nitrobenzoylacetate

: 1346441-18-6
1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / dichloromethane / 0.5 h / 20 °C

2: iron; ammonium chloride / tetrahydrofuran; water / 3 h / 60 °C

3: tetrahydrofuran / 20 °C

With iron; ammonium chloride; acetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2011.09.042

Reference yield:

: C₁₉H₁₅N₅O₃

: 1346441-18-6
1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / tetrahydrofuran; water / 3 h / 60 °C

2: tetrahydrofuran / 20 °C

With iron; ammonium chloride; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2011.09.042