(+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

Base Information

• Chemical Name: (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl
• CAS No.: 155566-49-7
• Molecular Formula: C₂₅H₁₈F₃O₄PS
• Molecular Weight: 502.45
• Mol file: 155566-49-7.mol

Synonyms:(+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

Chemical Property of (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

There total 6 articles about (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (17763-95-0) + Diphenylphosphine oxide (4559-70-0) → (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (155566-49-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate;

DOI:10.1055/s-2006-933100

Reference yield: 58.0%

trifluoromethylsulfonic anhydride (358-23-6) + (2'-hydroxy-[1,1'-biphenyl]-2-yl)diphenylphosphine oxide (843615-09-8) → (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (155566-49-7)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃; Reflux;

DOI:10.1007/s11426-010-4172-z

Reference yield:

2,2'-dihydroxybiphenyl (1806-29-7) → (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (155566-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / pyridine

2: 83 percent / dppb; i-Pr₂EtN / Pd(OAc)2

With pyridine; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate;

DOI:10.1055/s-2006-933100

upstream raw materials:

2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

Diphenylphosphine oxide

2,2'-dihydroxybiphenyl

p-chlorodibenzo[c.e][1,2]oxaphosphorine

Downstream raw materials:

2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester

(S)-2'-(diphenylphosphoryl)-N-(1-hydroxy-3-methylbutan-2-yl)biphenyl-2-carboxamide

(S)-2'-(diphenylphosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

(S)-2'-(diphenylphosphoryl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)biphenyl-2-carboxamide