(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide
CAS No.:1375277-44-3
Molecular Formula:C₃₀H₂₉N₃O₅
Molecular Weight:511.577
Hs Code.:

Synonyms:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

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Technology Process of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

There total 3 articles about (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1375278-71-9
2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetic acid

: 1375278-62-8
(S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide

: 1375277-44-3
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 62995-59-9
(2-methyl-1H-indol-3-yl)oxoacetic acid methyl ester

: 1375277-44-3
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil / 0.33 h / 0 °C

1.2: 2 h / 0 °C

1.3: pH 4 / Cooling with ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; mineral oil;

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 1375277-44-3
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-indol-3-yl)-2-oxoacetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.5 h / 0 °C

1.2: 0.5 h

2.1: sodium hydride / mineral oil / 0.33 h / 0 °C

2.2: 2 h / 0 °C

2.3: pH 4 / Cooling with ice

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; mineral oil;