2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Base Information

Chemical Name:2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid
CAS No.:1266118-92-6
Molecular Formula:C₂₄H₃₂F₃NO₄S
Molecular Weight:487.584
Hs Code.:

Synonyms:2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Suppliers and Price of 2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

There total 9 articles about 2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₀F₃NO₄S

: 1266118-92-6
2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Guidance literature:: With ethanol; sodium cyanoborohydride; Reflux;

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1266118-92-6
2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / butanone; tert-butyl alcohol / 0.17 h / 110 °C

1.2: 15 h / 110 °C / Inert atmosphere

2.1: N-iodo-succinimide / zirconium(IV) chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.5 h / -78 °C

5.1: ethanol / 1 h / Reflux

6.1: ethanol; sodium cyanoborohydride / Reflux

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; n-butyllithium; ethanol; sodium cyanoborohydride; caesium carbonate; zirconium(IV) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; butanone; tert-butyl alcohol;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266118-92-6
2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-ylmethyl]-amino}-ethanesulfonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 26 h / 0 - 30 °C

3.1: N-iodo-succinimide / zirconium(IV) chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

5.2: 1.5 h / -78 °C

6.1: ethanol / 1 h / Reflux

7.1: ethanol; sodium cyanoborohydride / Reflux

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; n-butyllithium; ethanol; di-isopropyl azodicarboxylate; sodium cyanoborohydride; triethylamine; triphenylphosphine; zirconium(IV) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;