methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate
CAS No.:1612148-74-9
Molecular Formula:C₂₀H₁₂ClF₂N₃O₂
Molecular Weight:399.784
Hs Code.:

Synonyms:methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

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Chemical Property of methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

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Technology Process of methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

There total 2 articles about methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 786727-08-0
(7-chloroquinolin-4-yl)-hydrazine hydrochloride

: 1612148-67-0
sodium methyl 4-(2,6-difluorophenyl)-2,4-dioxobutanoate

: 1612148-74-9
methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: With hydrogenchloride; acetic acid; In water; Inert atmosphere; Reflux;
DOI:10.1021/jm5003843

Reference yield: 52.0%

: 1612148-74-9
methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: With hydrogenchloride; acetic acid; for 5h; Reflux; Inert atmosphere;

Reference yield: 94.0%

: 1612148-74-9
methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate

: 1612148-83-0
1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-difluorophenyl)-1H-pyrazole-3-carboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;
DOI:10.1021/jm5003843