C₂₇H₂₂FNO₅S

Base Information

• Chemical Name: C₂₇H₂₂FNO₅S
• CAS No.: 1374235-04-7
• Molecular Formula: C₂₇H₂₂FNO₅S
• Molecular Weight: 491.54
• Mol file: 1374235-04-7.mol

Synonyms:C₂₇H₂₂FNO₅S

Chemical Property of C₂₇H₂₂FNO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₂FNO₅S

There total 7 articles about C₂₇H₂₂FNO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C27H23BrFNO5S (1374235-03-6) → C27H22FNO5S (1374235-04-7)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 80 ℃; Inert atmosphere;

Reference yield:

ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate (691857-46-2) → C27H22FNO5S (1374235-04-7)

Guidance literature:

Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 2 h / 60 °C / Inert atmosphere

3: acetic acid; zinc / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C

4: pyridine / dmap / dichloromethane / 3 h / 0 - 20 °C

5: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 70 °C

6: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 80 °C / Inert atmosphere

With pyridine; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate (691857-07-5) → C27H22FNO5S (1374235-04-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 2 h / 60 °C / Inert atmosphere

4.1: acetic acid; zinc / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C

5.1: pyridine / dmap / dichloromethane / 3 h / 0 - 20 °C

6.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 70 °C

7.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 80 °C / Inert atmosphere

With pyridine; boron trichloride; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

C₁₉H₁₄FNO₅

Downstream raw materials:

C₂₇H₂₄FNO₅S