((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

Base Information

Chemical Name:((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid
CAS No.:1386395-59-0
Molecular Formula:C₁₀H₁₃FNO₆P
Molecular Weight:293.188
Hs Code.:

Synonyms:((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

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Chemical Property of ((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

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Technology Process of ((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

There total 5 articles about ((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1386395-45-4
diethyl [(4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl]phosphonate

: 1386395-59-0
((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

Guidance literature:: diethyl [(4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl]phosphonate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 24h;

In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1021/jm300652f

Reference yield:

: 1386395-37-4
diethyl ((2-((benzyloxy)(methyl)amino)-2-oxoethoxy)(4-fluorophenyl)methyl)phosphonate

: 1386395-59-0
((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

2.1: trimethylsilyl bromide / dichloromethane / 24 h / 0 - 20 °C

2.2: 1 h / 20 °C

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;
DOI:10.1021/jm300652f

Reference yield:

: 1386395-29-4
2-[(diethoxyphosphoryl)(4-fluorophenyl)methoxy]acetic acid

: 1386395-59-0
((4-fluorophenyl)(2-(hydroxy(methyl)amino)-2-oxoethoxy)methyl)phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 12 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

3.1: trimethylsilyl bromide / dichloromethane / 24 h / 0 - 20 °C

3.2: 1 h / 20 °C

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;
DOI:10.1021/jm300652f