Technology Process of 6,7-Dimethoxy-1-(3,4,5-triiodobenzyl)-1,2,3,4-tetrahydroisoquinoline
There total 9 articles about 6,7-Dimethoxy-1-(3,4,5-triiodobenzyl)-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol; water;
for 1.5h;
Heating;
DOI:10.1021/jm960208o
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / tetrahydrofuran / Ambient temperature
2: 87 percent / H2 / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr
3: 44 percent / benzyltrimethylammonium dichloroiodate, CaCO3 / CH2Cl2; methanol / Ambient temperature
4: 1.) NaNO2, conc. H2SO4, gl. acetic acid, 2.) aq. KI / 1.) 0 - 5 deg C, 2.) water, 80 deg C
5: 76 percent / K2CO3 / methanol; H2O / 1.5 h / Heating
With
sulfuric acid; hydrogen; potassium carbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; calcium carbonate; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm960208o
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 58 percent / toluene / 72 h / Heating
2: POCl3 / acetonitrile / 4 h / Heating
3: NaBH4 / methanol / Ambient temperature
4: 50 percent / tetrahydrofuran / Ambient temperature
5: 87 percent / H2 / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr
6: 44 percent / benzyltrimethylammonium dichloroiodate, CaCO3 / CH2Cl2; methanol / Ambient temperature
7: 1.) NaNO2, conc. H2SO4, gl. acetic acid, 2.) aq. KI / 1.) 0 - 5 deg C, 2.) water, 80 deg C
8: 76 percent / K2CO3 / methanol; H2O / 1.5 h / Heating
With
sodium tetrahydroborate; sulfuric acid; hydrogen; potassium carbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; calcium carbonate; potassium iodide; sodium nitrite; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm960208o