rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Base Information

• Chemical Name: rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
• CAS No.: 1265682-11-8
• Molecular Formula: C₁₄H₁₇N₃O₄
• Molecular Weight: 291.307
• Mol file: 1265682-11-8.mol

Synonyms:rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Chemical Property of rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

There total 10 articles about rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-{4-[5-aminomethyI-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morphoIine-3-one acetate (1411711-66-4) → rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one (1265682-11-8,1411775-06-8)

Guidance literature:

With sodium hydroxide; In water; at 5 - 25 ℃; pH=10 - 11;

Reference yield:

{2-oxo-3-[4-(3-oxomorpholino)phenyl]oxazolidin-5-yl}methyl 4-nitrobenzenesulfonate → rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one (1265682-11-8,1411775-06-8)

Guidance literature:

With ammonium hydroxide; In isopropyl alcohol; acetonitrile; at 80 ℃; for 16h; Schlenk technique;

DOI:10.1002/ejoc.201600033

Reference yield:

4-{4-[5-[(dibenzylamino)methyl]-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholine-3-one (1411775-03-5) → rac-4-[4-[5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one (1265682-11-8,1411775-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / 24 h / 20 °C / 7500.75 Torr

2: sodium hydroxide / water / 5 - 25 °C / pH 10 - 11

With hydrogen; sodium hydroxide; palladium 10% on activated carbon; In water;

upstream raw materials:

4-(4-aminophenyl)morpholin-3-one

4-{4-[5-[(dibenzylamino)methyl]-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholine-3-one

4-{4-[5-iodomethyl-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morpholine-3-one

4-{4-[5-aminomethyI-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morphoIine-3-one acetate

Downstream raw materials:

5-chloro-N-({(5)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide