Technology Process of (4aS)-7β-Ethenyl-3,4,4a,4bβ,5,6,7,9,10,10aβ-decahydro-9β-hydroxy-1,1,4aα,7-tetramethyl-2(1H)-phenanthrenone
There total 11 articles about (4aS)-7β-Ethenyl-3,4,4a,4bβ,5,6,7,9,10,10aβ-decahydro-9β-hydroxy-1,1,4aα,7-tetramethyl-2(1H)-phenanthrenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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30295-03-5
(4aS,4bR,7S,10aS)-1,1,4a,7-Tetramethyl-7-vinyl-3,4,4a,4b,5,6,7,9,10,10a-decahydro-1H-phenanthren-2-one
- Guidance literature:
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With
selenium(IV) oxide; water;
In
acetic acid; benzene;
at 62 - 63 ℃;
for 0.025h;
Yield given;
DOI:10.1016/S0040-4020(01)91369-9
- Guidance literature:
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Multi-step reaction with 9 steps
1: imidazole / dimethylformamide / 20 h / 25 - 30 °C
2: 1.)NaBH4 2.)CdCO3, HgCl2 / 1.)EtOH, THF, 2 h, 10 deg C. 2.)EtOH, reflux, 5 min
3: t-BuOK / benzene; 2-methyl-propan-2-ol / 1 h
4: 1.)n-BuLi / 1.)Hexane, THF, 10 min, 0-5 deg C. 2.)THF, overnight room temp.
5: aq HF / acetonitrile / 1.5 h / Ambient temperature
6: 42 percent / p-TsOH*H2O / benzene / 1 h / Heating
7: 95 percent / aq HCl / methanol / 0.25 h / Ambient temperature
8: CrO3 / acetone / 0.05 h / 0 - 5 °C
9: SeO2, H2O / benzene; acetic acid / 0.03 h / 62 - 63 °C
With
1H-imidazole; chromium(VI) oxide; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; selenium(IV) oxide; cadmium(II) carbonate; hydrogen fluoride; potassium tert-butylate; water; toluene-4-sulfonic acid; mercury dichloride;
In
methanol; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)91369-9
- Guidance literature:
-
Multi-step reaction with 10 steps
1: KOH / methanol; H2O
2: imidazole / dimethylformamide / 20 h / 25 - 30 °C
3: 1.)NaBH4 2.)CdCO3, HgCl2 / 1.)EtOH, THF, 2 h, 10 deg C. 2.)EtOH, reflux, 5 min
4: t-BuOK / benzene; 2-methyl-propan-2-ol / 1 h
5: 1.)n-BuLi / 1.)Hexane, THF, 10 min, 0-5 deg C. 2.)THF, overnight room temp.
6: aq HF / acetonitrile / 1.5 h / Ambient temperature
7: 42 percent / p-TsOH*H2O / benzene / 1 h / Heating
8: 95 percent / aq HCl / methanol / 0.25 h / Ambient temperature
9: CrO3 / acetone / 0.05 h / 0 - 5 °C
10: SeO2, H2O / benzene; acetic acid / 0.03 h / 62 - 63 °C
With
1H-imidazole; chromium(VI) oxide; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; selenium(IV) oxide; cadmium(II) carbonate; hydrogen fluoride; potassium tert-butylate; water; toluene-4-sulfonic acid; mercury dichloride;
In
methanol; water; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)91369-9
