7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

Base Information

Chemical Name:7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline
CAS No.:222968-93-6
Molecular Formula:C₂₉H₄₂N₂O₃Si
Molecular Weight:494.75
Hs Code.:

7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-<i>de</i>]quinoline

Synonyms:7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

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Chemical Property of 7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

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Technology Process of 7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

There total 9 articles about 7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1026612-07-6
8-methoxy-7-(4-methoxymethoxy-phenyl)-1-triisopropylsilanyl-1,3,4,7-tetrahydro-6-oxa-1,4a-diaza-cyclopenta[cd]phenalen-5-one

: 222968-93-6
7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; ethyl acetate; for 6h; Ambient temperature;
DOI:10.1016/S0040-4039(99)00034-9

Reference yield:

: 212829-61-3
(4-Chloro-6-methoxy-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-dimethyl-amine

: 222968-93-6
7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / toluene / 15 h / 0 °C

2: 80 percent / toluene / 0.33 h / 0 °C

3: 96 percent / LiAlH₄ / benzene; diethyl ether / 0.5 h / Heating

4: 70 percent / lithium isopropylcyclohexylamide / tetrahydrofuran / 0.25 h / 0 °C

5: 96 percent / 8 h / Heating

6: 1.) s-BuLi, TMEDA / 1.) Et₂O, -78 deg C, 1 h

7: 86 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

8: 93 percent / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 6 h / Ambient temperature

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; sodium hydride; lithium cyclohexylisopropylamide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4039(99)00034-9

Reference yield:

: 212829-60-2
(6-Methoxy-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-dimethyl-amine

: 222968-93-6
7-methoxy-6-(4-methoxymethoxy-benzyl)-1-triisopropylsilanyl-1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]quinoline

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) t-BuLi, 2.) Cl₃CCCl₃ / 1.) Et₂O, 0 deg C, 1 h

2: 78 percent / toluene / 15 h / 0 °C

3: 80 percent / toluene / 0.33 h / 0 °C

4: 96 percent / LiAlH₄ / benzene; diethyl ether / 0.5 h / Heating

5: 70 percent / lithium isopropylcyclohexylamide / tetrahydrofuran / 0.25 h / 0 °C

6: 96 percent / 8 h / Heating

7: 1.) s-BuLi, TMEDA / 1.) Et₂O, -78 deg C, 1 h

8: 86 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

9: 93 percent / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 6 h / Ambient temperature

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; hexachloroethane; hydrogen; tert.-butyl lithium; sec.-butyllithium; sodium hydride; lithium cyclohexylisopropylamide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4039(99)00034-9