tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate

Base Information

• Chemical Name: tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate
• CAS No.: 418753-59-0
• Molecular Formula: C₂₄H₂₃N₃O₃S
• Molecular Weight: 433.531
• Mol file: 418753-59-0.mol

Synonyms:tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate

Chemical Property of tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate

There total 1 articles about tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-Diazo-3-trimethylsilanyloxy-but-3-enoic acid tert-butyl ester (418754-05-9) → tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate (418753-59-0)

Guidance literature:

With mercury(II) diacetate; In dichloromethane; at 20 ℃;

DOI:10.1021/ol016995n

Reference yield: 89.0%

tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate (418753-59-0) → tert-butyl 4-benzyl-5-oxo-2-phenyl-5,6-dihydro-4H-thieno[3,2-b]pyrrole-6-carboxylate

Guidance literature:

dirhodium tetracetate dihydrate; In benzene; for 0.5h; Heating;

DOI:10.1021/ol016995n

Reference yield:

tert-butyl 3-(3-benzylamino-5-phenylthiophen-2-yl)-2-diazo-3-oxopropanoate (418753-59-0) → 4,4'-dibenzyl-5,5'-dioxo-2,2'-diphenyl-4,5,4',5'-tetrahydro-[6,6']bi[thieno[3,2-b]pyrrolyl]-6,6'-dicarboxylic acid di-tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Rh₂(OAc)4*2H₂O / benzene / 0.5 h / Heating

2: 91 percent / Cu(OAc)2*H₂O / ethanol / 0.5 h / 20 °C

With copper diacetate; dirhodium tetracetate dihydrate; In ethanol; benzene;

DOI:10.1021/ol016995n

upstream raw materials:

2-Diazo-3-trimethylsilanyloxy-but-3-enoic acid tert-butyl ester