[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol

Base Information

• Chemical Name: [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol
• CAS No.: 1147550-69-3
• Molecular Formula: C₂₀H₁₇F₂NO₂
• Molecular Weight: 341.357

Synonyms:[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol

Chemical Property of [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol

Chemical Property:

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Technology Process of [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol

There total 1 articles about [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-dicarboxylic acid dimethyl ester (1147550-72-8) → [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol (1147550-69-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; at 0 - 5 ℃;

DOI:10.1016/j.bmc.2010.11.030

Reference yield: 83.0%

[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol (1147550-69-3) + Isopropyl isocyanate (1795-48-8) → [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]bis(methylene) bis(iso-propylcarbamate) (1262971-97-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.11.030

Reference yield: 77.0%

[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]dimethanol (1147550-69-3) + methyl isocyanate (624-83-9) → [3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]bis(methylene) bis(methylcarbamate) (1147550-73-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.11.030

upstream raw materials:

3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-dicarboxylic acid dimethyl ester

Downstream raw materials:

[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]bis(methylene) bis(methylcarbamate)

[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]bis(methylene) bis(ethylcarbamate)

[3-(3,4-difluorophenyl)-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-diyl]bis(methylene) bis(iso-propylcarbamate)

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