4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

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Chemical Name:4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate
CAS No.:1311269-15-4
Molecular Formula:C₃₄H₃₈N₆O₅S
Molecular Weight:642.779
Hs Code.:

4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

Synonyms:4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

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Chemical Property of 4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

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Technology Process of 4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

There total 7 articles about 4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1311269-32-5
(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 88-10-8
N,N-diethylcarbamyl chloride

: 1311269-15-4
4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-30-3
(3R)-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 1311269-15-4
4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

2.2: 20 °C / Iknert atmosphere

3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; toluene;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-28-9
(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 1311269-15-4
4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N,N-diethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

1.2: 20 °C / Iknert atmosphere

2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; toluene;
DOI:10.1002/anie.201101210