N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

Base Information

Chemical Name:N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine
CAS No.:852333-54-1
Molecular Formula:C₃₂H₃₁N₃O₈
Molecular Weight:585.613
Hs Code.:

N<sub>2</sub>',O<sub>3</sub>'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

Synonyms:N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

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Technology Process of N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

There total 2 articles about N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 852333-53-0
2,2'-anhydro-3'-O-(N-methylcarbamoyl)-5'-O-(4,4'-dimethoxytrityl)uridine

: 852333-54-1
N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/ol0502432

Reference yield:

: 173170-12-2
2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil

: 852333-54-1
N₂',O₃'-carbonyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(methylamino)uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIEA / CH₂Cl₂ / 16 h / 20 °C

1.2: 87 percent / CH₂Cl₂; ethanol / 4 h / 20 °C

2.1: 88 percent / NaH / tetrahydrofuran / 2 h / Heating

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0502432