tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

Base Information

Chemical Name:tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate
CAS No.:529496-45-5
Molecular Formula:C₂₇H₃₉N₃O₆S
Molecular Weight:533.689
Hs Code.:

Synonyms:tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

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Chemical Property of tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

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Technology Process of tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

There total 8 articles about tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 238405-88-4
(R)-2-(7-{[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl)-4-methyl-pentanoic acid tert-butyl ester

: 529496-45-5
tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃;
DOI:10.1021/jm020475w

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 529496-45-5
tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 5 h / 20 °C

2: 104 mg / sodium borohydride / ethanol / 20 °C

With sodium tetrahydroborate; In ethanol;
DOI:10.1021/jm020475w

Reference yield:

: 1656-44-6
2,4-dinitrobenzenesulfonyl chloride

: 529496-45-5
tert-butyl (2R)-2-[7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / dioxane / 20 °C

2: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

3: Fe; aq. acetic acid / 1.5 h / 60 °C

4: N-methylmorpholine / dimethylformamide / 80 °C

5: ethanol / 5 h / 20 °C

6: 104 mg / sodium borohydride / ethanol / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; iron; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jm020475w