(4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone

Base Information

Chemical Name:(4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone
CAS No.:1312713-53-3
Molecular Formula:C₂₅H₃₀FN₃O₂
Molecular Weight:423.531
Hs Code.:

Synonyms:(4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone

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Technology Process of (4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone

There total 2 articles about (4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1312713-70-4
(4-(tert-butyl)phenyl)(2-isopropyl-4-methylenepyrazolidin-1-yl)methanone

: 39502-43-7
2-fluoro-N-hydroxybenzenecarboxymidoyl chloride

: 1312713-53-3
(4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1021/jo200924y

Reference yield:

: 1312713-67-9
4-(tert-butyl)-N'-isopropylbenzohydrazide

: 1312713-53-3
(4-(tert-butyl)phenyl)(3-(2-fluorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice; Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jo200924y