E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate

Base Information

• Chemical Name: E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate
• CAS No.: 946570-35-0
• Molecular Formula: C₂₉H₄₄O₅
• Molecular Weight: 472.665
• Mol file: 946570-35-0.mol

Synonyms:E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate

Chemical Property of E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate

There total 7 articles about E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

5-methyl-3-(2-methylpropyl)hexanoyl chloride + E-5-(hydroxymethyl)-3-(3-methylbutylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one (946570-31-6) → E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate (946570-35-0)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 0 - 20 ℃; for 0.166667h;

DOI:10.1021/jm0702579

Reference yield:

E-5-[(4-methoxyphenoxy)methyl]-3-(3-methylbutylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one (946570-26-9) → E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate (946570-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.25 h / 0 °C

2: 47 percent / Et₃N / dimethylaminopyridine / CH₂Cl₂ / 0.17 h / 0 - 20 °C

With ammonium cerium(IV) nitrate; triethylamine; dmap; In dichloromethane; water; acetonitrile;

DOI:10.1021/jm0702579

Reference yield:

C25H32O6 → E-{4-(3-methylbutylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 5-methyl-3-(2-methylpropyl)hexanoate (946570-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Et₃N; methanesulfonyl chloride / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 512 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 20 °C

2.1: 100 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.25 h / 0 °C

3.1: 47 percent / Et₃N / dimethylaminopyridine / CH₂Cl₂ / 0.17 h / 0 - 20 °C

With ammonium cerium(IV) nitrate; methanesulfonyl chloride; triethylamine; dmap; In dichloromethane; water; acetonitrile;

DOI:10.1021/jm0702579

upstream raw materials:

E-5-(hydroxymethyl)-3-(3-methylbutylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one

E-5-[(4-methoxyphenoxy)methyl]-3-(3-methylbutylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one

1-(benzyloxy)-3-(4-methoxyphenoxy)acetone

1-(benzyloxy)-2-[(4-methoxyphenoxy)methyl]-4-penten-2-ol