2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Base Information

Chemical Name:2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1426307-84-7
Molecular Formula:C₂₂H₁₈FN₅O₂
Molecular Weight:403.416
Hs Code.:

Synonyms:2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 7 articles about 2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228787-11-8
4-amino-2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1426309-17-2
2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1426307-84-7
2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With diiodomethane; isopentyl nitrite; at 85 ℃;

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 1426309-17-2
2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1426307-84-7
2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -70 - 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: sodium hydroxide; boron trifluoride diethyl etherate / water; ethylene glycol / 5 h / 120 °C

3.1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.23 h / 140 - 170 °C

3.2: 0.25 h / Cooling with ice

4.1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

5.1: isopentyl nitrite; diiodomethane / 85 °C

With copper(l) iodide; diiodomethane; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hexamethyldisilazane; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; ethylene glycol; tert-butyl alcohol;

Reference yield:

: 451-82-1
(2-fluorophenyl)acetic acid

: 1426309-17-2
2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1426307-84-7
2-[3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-hydroxy-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -70 - 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: sodium hydroxide; boron trifluoride diethyl etherate / water; ethylene glycol / 5 h / 120 °C

3.1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.23 h / 140 - 170 °C

3.2: 0.25 h / Cooling with ice

4.1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

5.1: isopentyl nitrite; diiodomethane / 85 °C

With copper(l) iodide; diiodomethane; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hexamethyldisilazane; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; ethylene glycol; tert-butyl alcohol;