C₁₄H₁₂N₂O₄

Base Information

• Chemical Name: C₁₄H₁₂N₂O₄
• CAS No.: 1309611-45-7
• Molecular Formula: C₁₄H₁₂N₂O₄
• Molecular Weight: 272.26
• Mol file: 1309611-45-7.mol

Synonyms:C₁₄H₁₂N₂O₄

Chemical Property of C₁₄H₁₂N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₂N₂O₄

There total 8 articles about C₁₄H₁₂N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 6-(benzyloxycarbonylamino)-pyridine-2-carboxylate (1262043-88-8) → C14H12N2O4 (1309611-45-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2017.05.069

Reference yield:

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) → C14H12N2O4 (1309611-45-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / water / 12 h / 20 °C

2: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C

3: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling

4: toluene / 30 h / 120 °C

5: sodium hydroxide / 1,4-dioxane; water / 20 °C

With 4-methyl-morpholine; sodium azide; chloroformic acid ethyl ester; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1039/c1cc11532d

Reference yield:

6-(methoxycarbonyl)pyridine-2-carboxylic acid (7170-36-7) → C14H12N2O4 (1309611-45-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C

2: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling

3: toluene / 30 h / 120 °C

4: sodium hydroxide / 1,4-dioxane; water / 20 °C

With 4-methyl-morpholine; sodium azide; chloroformic acid ethyl ester; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1039/c1cc11532d

upstream raw materials:

2,6-bis(methoxycarbonyl)pyridine

methyl 6-(benzyloxycarbonylamino)-pyridine-2-carboxylate

Pyridine-2,6-dicarboxylic acid

6-(methoxycarbonyl)pyridine-2-carboxylic acid

Downstream raw materials:

C₂₀H₁₆N₄O₅

C₂₇H₂₂N₆O₆

C₂₈H₂₄N₆O₇

C₃₃H₂₆N₈O₇