(2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

Base Information

Chemical Name:(2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid
CAS No.:944913-78-4
Molecular Formula:C₂₆H₃₄O₇
Molecular Weight:458.552
Hs Code.:

Synonyms:(2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

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Chemical Property of (2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

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Technology Process of (2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

There total 10 articles about (2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026344-34-2
(2R,3S,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanal

: 944913-78-4
(2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.5h; Yield given;
DOI:10.1016/0040-4039(94)85043-7

Reference yield:

: 158783-80-3
2-[(1R,2R,3R,4S,5S)-2,6-Dihydroxy-4-(4-methoxy-benzyloxy)-1,3,5-trimethyl-hexyl]-6-ethyl-3,5-dimethyl-pyran-4-one

: 944913-78-4
(2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 2 h / -78 - -30 °C

2: NaClO₂; NaH₂PO₄; Me₂C=CHMe / 2-methyl-propan-2-ol; H₂O / 1 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.200700501

Reference yield:

: 944913-77-3
C₃₈H₆₆O₆Si₂

: 944913-78-4
(2R,3R,4S,6S)-6-(6-Ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / tris(dimethylamino)sulfonium difluorotrimethylsilicate / dimethylformamide / 4 h / 22 °C

2: (COCl)2; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 2 h / -78 - -30 °C

3: NaClO₂; NaH₂PO₄; Me₂C=CHMe / 2-methyl-propan-2-ol; H₂O / 1 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; tris(dimethylamino)sulfonium trimethylsilyldifluoride; dimethyl sulfoxide; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/anie.200700501