Technology Process of Dexloxiglumide
There total 3 articles about Dexloxiglumide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 3h;
under 2250.23 - 3000.3 Torr;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 4 h / 60 °C
2.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -10 °C
2.2: 5 h / -10 °C
2.3: 1 h / 20 °C
3.1: sodium carbonate / tetrahydrofuran / 1 h / 0 - 5 °C
4.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C / 2250.23 - 3000.3 Torr
With
4-methyl-morpholine; 5%-palladium/activated carbon; hydrogen; sodium carbonate; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -10 °C
1.2: 5 h / -10 °C
1.3: 1 h / 20 °C
2.1: sodium carbonate / tetrahydrofuran / 1 h / 0 - 5 °C
3.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C / 2250.23 - 3000.3 Torr
With
4-methyl-morpholine; 5%-palladium/activated carbon; hydrogen; sodium carbonate; isobutyl chloroformate;
In
tetrahydrofuran; methanol;
