Synonyms:Glycosides,sapogenin;Sapogenins, glycosides;Saponins;Saponosides;Tea Saponin;
85%, *data from raw suppliers
Xi
Xi:Irritant;The research aimed to synthesize and biologically evaluate 22-deoxo-23-oxa analogues of the saponin OSW-1, which is known for its potent cytotoxic properties against various cancer cells. The purpose was to develop simpler OSW-1 analogues that retain high and selective anticancer activity while being less toxic to normal cells, thus widening the therapeutic window. The study successfully synthesized a series of OSW-1 analogues and tested their ability to inhibit cancer cell proliferation and induce apoptosis. The analogues were found to be slightly less active than OSW-1 but demonstrated significantly less toxicity to normal human fibroblasts, suggesting a broader therapeutic window. Key chemicals used in the synthesis process included steroidal 16β,17R,22-triol as the starting material, various carboxylic acids for esterification, and protecting groups such as triethylsilyl and acetyl groups. The synthesized analogues were then screened against eight cancer cell lines and normal human fibroblasts, with the results indicating that the analogues could induce concentration- and time-dependent apoptosis in mammalian cancer cells with caspase-3 activation.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
