L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

Base Information

Chemical Name:L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester
CAS No.:871927-89-8
Molecular Formula:C₂₈H₃₃N₃O₁₀
Molecular Weight:571.584
Hs Code.:

Synonyms:L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

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Chemical Property of L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

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Technology Process of L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

There total 3 articles about L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 871927-91-2
N-tert-butoxycarbonyl-L-aspartyl-(β-benzyl ester)-L-aspartyl-(β-benzyl ester)-L-aspartic acid dimethyl ester

: 871927-89-8
L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

Guidance literature:: N-tert-butoxycarbonyl-L-aspartyl-(β-benzyl ester)-L-aspartyl-(β-benzyl ester)-L-aspartic acid dimethyl ester; With 1-(Trimethylsilyl)imidazole; In acetonitrile; for 0.0833333h;

With methanol; In acetonitrile; for 0.0333333h;
DOI:10.1021/jo051403q

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 871927-89-8
L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 45 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / CH₂Cl₂ / 15 h

2.1: 1-(trimethylsilyl)imidazole / acetonitrile / 0.08 h

2.2: 95 percent / methanol / acetonitrile / 0.03 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-(Trimethylsilyl)imidazole; In dichloromethane; acetonitrile;
DOI:10.1021/jo051403q

Reference yield:

: 871927-90-1
α-L-aspartyl β-benzyl ester L-aspartic acid dimethyl ester

: 871927-89-8
L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 45 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / CH₂Cl₂ / 15 h

2.1: 1-(trimethylsilyl)imidazole / acetonitrile / 0.08 h

2.2: 95 percent / methanol / acetonitrile / 0.03 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-(Trimethylsilyl)imidazole; In dichloromethane; acetonitrile;
DOI:10.1021/jo051403q