4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester
• CAS No.: 1257235-12-3
• Molecular Formula: C₃₅H₄₆F₂N₄O₇
• Molecular Weight: 672.77

Synonyms:4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

Chemical Property of 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

There total 20 articles about 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-amino-3,3-dimethyl-butyryl)-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester (1257235-10-1) + (2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid (21691-41-8) → 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester (1257235-12-3)

Guidance literature:

With 4-methyl-morpholine; HATU; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 16h;

Reference yield:

N-Boc-4R-O-TBS-2R-aminoethyl-pyrrolidine (1245724-76-8) → 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester (1257235-12-3)

Guidance literature:

Multi-step reaction with 15 steps

1.1: dichloromethane / 0 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

5.1: borane / tetrahydrofuran / -30 - 0 °C

5.2: -10 - 0 °C

6.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

8.1: sodium acetate / 85 - 90 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

10.1: pyridine hydrogenfluoride / tetrahydrofuran / 0 - 20 °C

11.1: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C / Neat (no solvent)

12.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 2585.81 Torr

13.1: 4-methyl-morpholine; HATU / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

14.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 2585.81 Torr

15.1: 4-methyl-morpholine; HATU / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

With 4-methyl-morpholine; di-isopropyl azodicarboxylate; borane; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; dmap; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; benzene;

Reference yield:

4-(tert-butyl-dimethyl-silanyloxy)-2-(2-nitro-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (137934-80-6) → 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester (1257235-12-3)

Guidance literature:

Multi-step reaction with 17 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / -20 °C

2.1: hydrogen / Raney nickel / ethanol; water / 1 h / 2844.39 Torr

3.1: dichloromethane / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

5.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

7.1: borane / tetrahydrofuran / -30 - 0 °C

7.2: -10 - 0 °C

8.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

10.1: sodium acetate / 85 - 90 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

12.1: pyridine hydrogenfluoride / tetrahydrofuran / 0 - 20 °C

13.1: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C / Neat (no solvent)

14.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 2585.81 Torr

15.1: 4-methyl-morpholine; HATU / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

16.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 2585.81 Torr

17.1: 4-methyl-morpholine; HATU / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; borane; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; dmap; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; benzene;

upstream raw materials:

4-(2-amino-3,3-dimethyl-butyryl)-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

(2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid

N-Boc-4R-O-TBS-2R-aminoethyl-pyrrolidine

4-(tert-butyl-dimethyl-silanyloxy)-2-(2-nitro-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(1-{1-[6-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propylcarbamoyl}-ethyl)-methyl-carbamic acid benzyl ester

N-{1-[6-(3,4-difluoro-phenoxy)-4-methanesulfonyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propyl}-2-methylamino-propionamide

N-{1-[4-acetyl-6-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propyl}-2-methylamino-propionamide

3-(3,4-difluoro-phenoxy)-4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid methylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1257235-12-3 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(3,4-difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send