Technology Process of (1E,3E)-1-(4-carboethoxyphenyl)-2-methyl-4-(1,2-epoxy-2,6,6-trimethylcyclohex-1-yl)-1,3-butadiene
There total 5 articles about (1E,3E)-1-(4-carboethoxyphenyl)-2-methyl-4-(1,2-epoxy-2,6,6-trimethylcyclohex-1-yl)-1,3-butadiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 0.583333h;
DOI:10.1021/jm00137a019
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaH / dimethylformamide / 1.) RT, 16 h, 2.) 60 deg C, 45 min
2: 74 percent / Na2HPO4*7H2O, 85percent MCPBA / CH2Cl2 / 0.58 h / 0 °C
With
disodium hydrogenphosphate; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00137a019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi / 1.) THF, hexane, from -78 deg C to RT, 20 min, 2.) hexane, THF, a) RT, overnight, b) 60 deg C, 1 h
2: 52 percent / SeO2 / aq. ethanol / 19 h / Heating
3: 1.) t-BuOK / 1.) t-BuOH, THF, 0 deg C, 15 min, 2.) t-BuOH, THF, a) 0 deg C, 2 h, b) RT, 18 h
4: 74 percent / Na2HPO4*7H2O, 85percent MCPBA / CH2Cl2 / 0.58 h / 0 °C
With
disodium hydrogenphosphate; n-butyllithium; selenium(IV) oxide; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane;
DOI:10.1021/jm00137a019
