1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

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Chemical Name:1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate
CAS No.:1365838-75-0
Molecular Formula:C₂₆H₃₆N₈O₃S
Molecular Weight:540.69
Hs Code.:

Synonyms:1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

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Chemical Property of 1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

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Technology Process of 1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

There total 5 articles about 1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 247570-24-7
tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate

: 1365838-68-1
N-[2-chloro-6-(4-morpholinylmethyl)-4-pyrimidinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: 1365838-75-0
1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

Guidance literature:: In isopropyl alcohol; at 170 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1365838-65-8
2-chloro-6-(4-morpholinylcarbonyl)-N-(1,1,3,3-tetramethylbutyl)-4-pyrimidinamine

: 1365838-75-0
1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: pH 14

2.1: trifluoroacetic acid / dichloromethane / 20 - 40 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.08 h / 20 °C / Cooling

4.1: isopropyl alcohol / 1 h / 170 °C / Microwave irradiation

With borane-THF; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1365838-64-7
methyl 2-chloro-6-((2,4,4-trimethylpentan-2-yl)amino)pyrimidine-4-carboxylate

: 1365838-75-0
1,1-dimethylethyl (cis-4-{[4-(4-morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / tetrahydrofuran / 3 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: pH 14

3.1: trifluoroacetic acid / dichloromethane / 20 - 40 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.08 h / 20 °C / Cooling

5.1: isopropyl alcohol / 1 h / 170 °C / Microwave irradiation

With borane-THF; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;