2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Base Information

• Chemical Name: 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester
• CAS No.: 343322-10-1
• Molecular Formula: C₂₄H₂₇N₃O₄S
• Molecular Weight: 453.562
• Mol file: 343322-10-1.mol

Synonyms:2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Chemical Property of 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

There total 10 articles about 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-2-[4-{[(4-methyl-2-[4-nitrophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester (343322-08-7) → 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester (343322-10-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 18h;

DOI:10.1021/jm058056x

Reference yield: 100.0%

→ 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester (343322-10-1)

Guidance literature:

Reference yield:

ethyl 4-methyl-2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate (15911-31-6) → 2-methyl-2-[4-{[(4-methyl-2-[4-aminophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester (343322-10-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / NaOH / ethanol; H₂O / 1.5 h / 85 °C

2: SOCl₂ / 3 h / Heating

3: Et₃N / CH₂Cl₂ / 20 °C

4: 100 percent / H₂ / Pd/C / ethanol / 18 h / 20 °C

With sodium hydroxide; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water;

DOI:10.1021/jm058056x

upstream raw materials:

2-methyl-2-[4-{[(4-methyl-2-[4-nitrophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

ethyl 4-methyl-2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate

ethyl 2-bromoisobutyrate

ethyl 2-{[4-(aminomethyl)phenyl]oxy}-2-methylpropanoate