(2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: (2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate
• CAS No.: 1221973-65-4
• Molecular Formula: C₁₇H₁₉NO₅
• Molecular Weight: 317.342
• Mol file: 1221973-65-4.mol

Synonyms:(2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate

Chemical Property of (2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate

There total 1 articles about (2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(3R,7S,7aR)-methyl 3-(tert-butyl)-7-hydroxy-6,6-dimethyl-5-oxo-7-(phenylethynyl)hexahydropyrrolo[1,2-c]oxazole-7a-carboxylate (1221973-59-6) → (2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate (1221973-65-4)

Guidance literature:

With 1.3-propanedithiol; hydrogenchloride; water; In 2,2,2-trifluoroethanol; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2010.02.066

Reference yield: 92.0%

(2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate (1221973-65-4) → 3-hydroxy-2-hydroxymethyl-4,4-dimethyl-5-oxo-3-phenylethynyl-pyrrolidine-2-carboxylic acid (1221973-70-1)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

DOI:10.1055/s-0030-1261197

Reference yield:

(2R,3S)-methyl 3-hydroxy-2-(hydroxymethyl)-4,4-dimethyl-5-oxo-3-(phenylethynyl)pyrrolidine-2-carboxylate (1221973-65-4) → 5-hydroxymethyl-3,3-dimethyl-4-phenylethynyl-1,3-dihydro-pyrrol-2-one (1345028-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; water; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol;

DOI:10.1055/s-0030-1261197

upstream raw materials:

(3R,7S,7aR)-methyl 3-(tert-butyl)-7-hydroxy-6,6-dimethyl-5-oxo-7-(phenylethynyl)hexahydropyrrolo[1,2-c]oxazole-7a-carboxylate

Downstream raw materials:

3-hydroxy-2-hydroxymethyl-4,4-dimethyl-5-oxo-3-phenylethynyl-pyrrolidine-2-carboxylic acid

5-hydroxymethyl-3,3-dimethyl-4-phenylethynyl-1,3-dihydro-pyrrol-2-one