4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester
CAS No.:141805-51-8
Molecular Formula:C₃₁H₄₃NO₈SSi
Molecular Weight:617.836
Hs Code.:

4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

Synonyms:4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

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Chemical Property of 4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

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Technology Process of 4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

There total 11 articles about 4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 84537-07-5
β-methoxyacryloyl chloride

: 141805-57-4
2-Amino-4,5-dimethoxy-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

: 141805-51-8
4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 25 ℃;

Reference yield:

: 141805-53-0
Imidazole-1-carbothioic acid O-((3aR,4S,6R,7S,7aR)-6-methoxy-4-methyl-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl) ester

: 141805-51-8
4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / n-Bu₃SnH / azobisisobutyronitrile (AIBN) / toluene; 1,2-dimethoxy-ethane / 1 h / 110 °C

2: ZnI₂, n-Bu₄NI / 1,2-dichloro-ethane / 2.5 h / 70 °C

3: NaH, ethanediol / tetrahydrofuran / 2 h / 25 °C

4: 1.) n-Bu₂SnO, 2.) Et₃N / 1.) MeOH, 65 deg C, 1.5 h, 2.) THF, 25 deg C, 0.75 h

5: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.2 h / 0 °C

6: 83 percent / hydrazine, AcOH / methanol; CH₂Cl₂ / 5 h / 25 °C

7: 85 percent / Et₃N / tetrahydrofuran / 25 °C

With 2,6-dimethylpyridine; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; ethylene glycol; acetic acid; triethylamine; zinc(II) iodide; hydrazine; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 4551-15-9
phenylthiotrimethylsilane

: 141805-51-8
4,5-Dimethoxy-2-(2-methoxy-acryloylamino)-benzoic acid (2S,3R,4S,6R)-2-methyl-6-phenylsulfanyl-3-triethylsilanyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ZnI₂, n-Bu₄NI / 1,2-dichloro-ethane / 2.5 h / 70 °C

2: NaH, ethanediol / tetrahydrofuran / 2 h / 25 °C

3: 1.) n-Bu₂SnO, 2.) Et₃N / 1.) MeOH, 65 deg C, 1.5 h, 2.) THF, 25 deg C, 0.75 h

4: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.2 h / 0 °C

5: 83 percent / hydrazine, AcOH / methanol; CH₂Cl₂ / 5 h / 25 °C

6: 85 percent / Et₃N / tetrahydrofuran / 25 °C

With 2,6-dimethylpyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; ethylene glycol; acetic acid; triethylamine; zinc(II) iodide; hydrazine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;