tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate
• CAS No.: 1240970-70-0
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 1240970-70-0.mol

Synonyms:tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate

Chemical Property of tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate

Chemical Property:

• Boiling Point: 396.2±42.0 °C(Predicted)
• Density: 1.159±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate

There total 4 articles about tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl-3-iodoazetidine-1-carboxylate (254454-54-1) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate (1240970-70-0)

Guidance literature:

With nickel(II) nitrate hexahydrate; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,4-dioxane; at 80 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201500346

Reference yield: 92.0%

4-methoxycarbonylphenyl bromide (619-42-1) + 3-bromo-azetidine-1-carboxylic acid tert-butyl ester (1064194-10-0) → tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate (1240970-70-0)

Guidance literature:

With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine]nickel(II) dichloride; tris-(trimethylsilyl)silane; [Ir[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine]₂(4,4′-di-t-Bu-2,2′-bipyridine)]PF₆; sodium carbonate; In 1,2-dimethoxyethane; at 20 ℃; for 6h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.6b04818

Reference yield:

methyl 4-iodobenzoate (619-44-3) + tert-butyl-3-iodoazetidine-1-carboxylate (254454-54-1) → tert-butyl 3-(4-(methoxycarbonyl)phenyl)azetidine-1-carboxylate (1240970-70-0)

Guidance literature:

tert-butyl-3-iodoazetidine-1-carboxylate; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; at 20 ℃; for 1.41667h;

methyl 4-iodobenzoate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; In tetrahydrofuran; at 65 ℃; for 18h; Inert atmosphere;

upstream raw materials:

methyl 4-iodobenzoate

tert-butyl-3-iodoazetidine-1-carboxylate

4-methoxycarbonylphenylboronic acid

4-methoxycarbonylphenyl bromide

Downstream raw materials:

tert-butyl 3-(4-(hydroxymethyl)phenyl)azetidine-1-carboxylate