(p-Iodophenyl)acetic acid Difluoride

Base Information

• Chemical Name: (p-Iodophenyl)acetic acid Difluoride
• CAS No.: 74925-02-3
• Molecular Formula: C₈H₇F₂IO₂
• Molecular Weight: 300.044
• Mol file: 74925-02-3.mol

Synonyms:(p-Iodophenyl)acetic acid Difluoride

Chemical Property of (p-Iodophenyl)acetic acid Difluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (p-Iodophenyl)acetic acid Difluoride

There total 3 articles about (p-Iodophenyl)acetic acid Difluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(p-Iodophenyl)acetic acid Dichloride (62349-86-4) → (p-Iodophenyl)acetic acid Difluoride (74925-02-3)

Guidance literature:

With hydrogen fluoride; mercury(II) oxide; In dichloromethane; for 0.166667h;

DOI:10.1021/jo01310a043

Reference yield:

(4-iodophenyl)acetic acid (1798-06-7) → (p-Iodophenyl)acetic acid Difluoride (74925-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Chlorine / CHCl₃ / 0.17 h / 0 °C

2: 95 percent / Mercuric oxide, 48percent HF / CH₂Cl₂ / 0.17 h

With hydrogen fluoride; chlorine; mercury(II) oxide; In dichloromethane; chloroform;

DOI:10.1021/jo01310a043

Reference yield:

4-aminophenylacetic acid (1197-55-3) → (p-Iodophenyl)acetic acid Difluoride (74925-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaNO₃; 2.) KI / 1.) water, HCl, 0 - 10 deg C

2: 86 percent / Chlorine / CHCl₃ / 0.17 h / 0 °C

3: 95 percent / Mercuric oxide, 48percent HF / CH₂Cl₂ / 0.17 h

With sodium nitrate; hydrogen fluoride; chlorine; potassium iodide; mercury(II) oxide; In dichloromethane; chloroform;

DOI:10.1021/jo01310a043

upstream raw materials:

(p-Iodophenyl)acetic acid Dichloride

(4-iodophenyl)acetic acid

4-aminophenylacetic acid

Downstream raw materials:

1,1-difluoro-1,2-diphenylethane

1-(2,2-difluoro-2-phenylethyl)-4-methoxybenzene

1,1-difluoro-2-phenylindane

C₁₄H₁₀Br₂F₂