(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol

Base Information

• Chemical Name: (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol
• CAS No.: 203795-85-1
• Molecular Formula: C₄₃H₅₆O₄
• Molecular Weight: 636.915
• Mol file: 203795-85-1.mol

Synonyms:(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol

Chemical Property of (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol

There total 3 articles about (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C50H59NO7 → (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol (203795-85-1)

Guidance literature:

With sodium hydroxide; In methanol; dichloromethane; water; at 60 ℃; for 24h; Heating / reflux;

Reference yield:

3β,7α,12α-trihydroxy-5β-cholan-24-oic acid methyl ester (28050-54-6) → (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol (203795-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: Et₃N / dimethylformamide

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja973881r

Reference yield:

trityl chloride (76-83-5) + (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-4-Hydroxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol → (3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol (203795-85-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja973881r

upstream raw materials:

trityl chloride

3β,7α,12α-trihydroxy-5β-cholan-24-oic acid methyl ester

Downstream raw materials:

(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-allyloxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene

2-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-Bis-(2-hydroxy-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethanol

Benzyl-methyl-{(R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(2-azido-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris-(2-azido-ethoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene