(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

Base Information

Chemical Name:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium
CAS No.:1400929-62-5
Molecular Formula:C₁₆H₂₅N₃O₅P*Li
Molecular Weight:377.306
Hs Code.:

Synonyms:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

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Chemical Property of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

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Technology Process of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

There total 7 articles about (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: N-(N-(benzyloxycarbonyl)-(R/S)-aminomethylphosphonyl)-N'-methyl-L-leucinamide methyl ester

: 1400929-62-5
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

Guidance literature:: With lithium hydroxide; In water; at 20 ℃; for 2h;
DOI:10.1021/jm300472k

Reference yield:

: 621-84-1
O-benzyl carbamate

: 1400929-62-5
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / water / 20 °C

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: 3 h / Reflux

4: sodium hydroxide / 2 h / 20 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6: lithium hydroxide / water / 2 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm300472k

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 1400929-62-5
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / methanol / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: lithium hydroxide / water / 2 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300472k