2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

Base Information

Chemical Name:2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol
CAS No.:1350324-15-0
Molecular Formula:C₁₅H₁₁BrClFN₂O
Molecular Weight:369.621
Hs Code.:

Synonyms:2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

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Chemical Property of 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

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Technology Process of 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

There total 7 articles about 2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350322-47-2
5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

: 1350324-15-0
2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

Guidance literature:: 5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 18.16h;

With methanol; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 1350325-32-4
5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)(1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine

: 1350324-15-0
2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

Guidance literature:: 5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)(1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine; With boron tribromide; In dichloromethane; at -78 - 20 ℃;

With methanol; ammonia; In dichloromethane; at 0 ℃;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1350324-15-0
2-[(1S)-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]-3-chloro-4-fluorophenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol / 12 h / 20 °C

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / -60 °C

2.2: -60 - 45 °C / Inert atmosphere

3.1: ChiralPak IA / carbon dioxide; methanol / Resolution of racemate

4.1: boron tribromide / dichloromethane / 18.16 h / -78 - 20 °C

4.2: 0.5 h / 0 - 20 °C

With boron trifluoride diethyl etherate; boron tribromide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide;