(S)-N-[1-(4-nitrophenyl)ethyl]acetamide

Base Information

• Chemical Name: (S)-N-[1-(4-nitrophenyl)ethyl]acetamide
• CAS No.: 4187-54-6
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.217
• Mol file: 4187-54-6.mol

Synonyms:(S)-N-[1-(4-nitrophenyl)ethyl]acetamide

Chemical Property of (S)-N-[1-(4-nitrophenyl)ethyl]acetamide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-[1-(4-nitrophenyl)ethyl]acetamide

There total 19 articles about (S)-N-[1-(4-nitrophenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-acetylamino-1-(4-nitrophenyl)ethene → (R)-N-acetyl-1-(4-nitrophenyl)ethylamine (4187-54-6,62398-11-2,90918-50-6,62532-38-1)

Guidance literature:

With hydrogen; [Rh(DiSquareP*)(nbd)]PF₆; In methanol; at 20 ℃; for 11h; under 760 Torr;

DOI:10.1055/s-2004-822396

Reference yield: 97.0%

1-acetylamino-1-(4-nitrophenyl)ethene → (S)-N-[1-(4-nitrophenyl)ethyl]acetamide (4187-54-6)

Guidance literature:

With (S)-di-1-adamantylphosphino(tert-butylmethylphosphino)methane(1,5-cyclooctadiene)rhodium(I) hexafluoroantimonate; hydrogen; In dichloromethane; for 4h; under 2280.15 Torr; enantioselective reaction; Catalytic behavior;

DOI:10.1021/acs.orglett.9b02702

Reference yield: 73.1%

→ (S)-N-[1-(4-nitrophenyl)ethyl]acetamide (4187-54-6)

Guidance literature:

With sulfuric acid; nitric acid; at -5 - 20 ℃; for 19h;

upstream raw materials:

(S)-N-acetyl-1-phenylethylamine

acetic anhydride

(S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide

(S)-1-(p-nitrophenyl)ethylamine

Downstream raw materials:

(R)-N-(1-(4-aminophenyl)ethyl)acetamide

(R)-1-acetylamino-4-(1-acetylamino-ethyl)-benzene

(S)-1-(p-nitrophenyl)ethylamine

(R)-2-methyl-p-nitrobenzylamine

Refernces

• 1、 Saito, Yuki,Kobayashi, Shu. "Development of robust heterogeneous chiral rhodium catalysts utilizing acid?base and electrostatic interactions for efficient continuous-flow asymmetric hydrogenations". supporting information. p. 16546 - 16551. Retrieved 2020/11/09.
• 2、 Sawatsugawa, Yuuki,Tamura, Ken,Sano, Natsuhiro,Imamoto, Tsuneo. "A Bulky Three-Hindered Quadrant Bisphosphine Ligand: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes". supporting information. p. 8874 - 8878. Retrieved 2019/11/03.