2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester
• CAS No.: 350238-16-3
• Molecular Formula: C₂₄H₂₈N₂O₇
• Molecular Weight: 456.496
• Mol file: 350238-16-3.mol

Synonyms:2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester

Chemical Property of 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester

There total 1 articles about 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

Gly-OBz (1738-68-7) + mono-t-butyl ester of N-benzyloxycarbonylaminomalonic acid (84245-57-8) → 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester (350238-16-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield: 83.0%

2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester (350238-16-3) → 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid (350238-00-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester (350238-16-3) → [(8-chloro-2-oxo-5-phenylcarbamoylmethylene-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-amino]-acetic acid benzyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / TFA / CH₂Cl₂

2: 74 percent / PCl₅; pyridine / tetrahydrofuran

3: 30 percent / HBr; AcOH / CH₂Cl₂

With pyridine; phosphorus pentachloride; hydrogen bromide; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(01)00402-6

upstream raw materials:

Gly-OBz

mono-t-butyl ester of N-benzyloxycarbonylaminomalonic acid

Downstream raw materials:

2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid

{2-Benzyloxycarbonylamino-2-[5-chloro-2-(2-phenylcarbamoyl-acetyl)-phenylcarbamoyl]-acetylamino}-acetic acid benzyl ester