(R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Base Information

Chemical Name:(R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one
CAS No.:1112968-16-7
Molecular Formula:C₁₅H₁₃F₃N₂O₄
Molecular Weight:342.274
Hs Code.:
Mol file:1112968-16-7.mol

Synonyms:(R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Suppliers and Price of (R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Chemical Property:

Boiling Point:508.3±50.0 °C(Predicted)
PKA:14.05±0.10(Predicted)
Density:1.522±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

There total 7 articles about (R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1239515-40-2
C₁₆H₁₇F₃N₂O₃

: 60456-26-0
(R)-glycidyl butyrate

: 1112968-16-7
(R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Guidance literature:: C₁₆H₁₇F₃N₂O₃; With lithium tert-butoxide; In tetrahydrofuran; acetonitrile; at 5 ℃; Inert atmosphere;

(R)-glycidyl butyrate; In tetrahydrofuran; acetonitrile; at 17 - 20 ℃;

Reference yield:

: 1112968-96-3
C₁₉H₁₅F₃N₂O₃

: 60456-26-0
(R)-glycidyl butyrate

: 1112968-16-7
(R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Guidance literature:: C₁₉H₁₅F₃N₂O₃; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

(R)-glycidyl butyrate; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1112968-93-0
C₁₁H₇F₃N₂O₃

: 1112968-16-7
(R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; iron; ammonium chloride / ethanol / 0.83 h / 100 - 105 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0 - 20 °C

2.3: 2 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

With water; iron; sodium hydride; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;