Technology Process of 3-chloro-2-(1‐(4-(trifluoromethoxy)benzyl)‐1H‐pyrazol-4‐yl)quinolin‐4(1H)-one
There total 7 articles about 3-chloro-2-(1‐(4-(trifluoromethoxy)benzyl)‐1H‐pyrazol-4‐yl)quinolin‐4(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2‐(1-(4‐(trifluoromethoxy)benzyl)-1H-pyrazol‐4-yl)quinolin‐4(1H)‐one;
With
sode de l'acide trichloroisocyanurique; sodium hydroxide;
In
methanol; water;
at 17 - 25 ℃;
With
hydrogenchloride;
In
methanol; water;
at 17 - 25 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 17 - 25 °C
1.2: 17 - 25 °C
2.1: phosphorus(V) oxybromide / chloroform / 1.5 h / 17 - 25 °C
2.2: pH 7 / cooling with ice-water
3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 24 h / Inert atmosphere; Reflux
4.1: water; acetic acid / 120 °C
4.2: 17 - 25 °C
5.1: sodium hydroxide; sode de l'acide trichloroisocyanurique / water; methanol / 17 - 25 °C
5.2: 17 - 25 °C
With
water; sode de l'acide trichloroisocyanurique; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; phosphorus(V) oxybromide;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
1,4-dioxane; methanol; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 90 °C
2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 24 h / Inert atmosphere; Reflux
3.1: water; acetic acid / 120 °C
3.2: 17 - 25 °C
4.1: sodium hydroxide; sode de l'acide trichloroisocyanurique / water; methanol / 17 - 25 °C
4.2: 17 - 25 °C
With
water; sode de l'acide trichloroisocyanurique; caesium carbonate; acetic acid; sodium hydroxide;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
