5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

Base Information

Chemical Name:5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine
CAS No.:1349770-40-6
Molecular Formula:C₂₃H₂₄N₆O₃S
Molecular Weight:464.548
Hs Code.:

Synonyms:5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

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Chemical Property of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

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Technology Process of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

There total 9 articles about 5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1349770-66-6
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

: 1349770-40-6
5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

Guidance literature:: tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-(5-isopropylsulfonyl-2-pyridyl)-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 52833-94-0
2-amino-5-bromonicotinicacid

: 1349770-40-6
5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 60 h / 20 °C

2.1: dibromotriphenylphosphorane; N-ethyl-N,N-diisopropylamine / acetonitrile / 15.67 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: dmap / tetrahydrofuran / 6 h / 20 °C

3.2: 82 h / 20 - 60 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Sealed tube; Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With dmap; potassium acetate; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibromotriphenylphosphorane; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1349770-57-5
tert-butyl N-[[4-[5-(2-amino-5-bromo-3-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

: 1349770-40-6
5-(5-isopropylsulfonyl-2-pyridyl)-3-[5-[4-(methylaminomethyl)phenyl]-1,3,4-oxadiazol-2-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 6 h / 20 °C

1.2: 82 h / 20 - 60 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Sealed tube; Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With dmap; potassium acetate; sodium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;