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(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide

Base Information Edit
  • Chemical Name:(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • CAS No.:196597-88-3
  • Molecular Formula:C16H23NO3
  • Molecular Weight:277.364
  • Hs Code.:
  • Mol file:196597-88-3.mol
(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide

Synonyms:(S)-N-[2-(6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

Suppliers and Price of (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • 1mg
  • $ 80.00
  • Biosynth Carbosynth
  • (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • 5 mg
  • $ 462.50
  • Biosynth Carbosynth
  • (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • 2 mg
  • $ 254.40
  • Biosynth Carbosynth
  • (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • 1 mg
  • $ 139.90
  • Biosynth Carbosynth
  • (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • 25 mg
  • $ 1529.00
  • Biosynth Carbosynth
  • (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide
  • 10 mg
  • $ 840.90
  • American Custom Chemicals Corporation
  • (S)-N-[2-[2,3-DIHYDRO-6-HYDROXY-7-(2-HYDROXYETHYL)-1H-INDEN-1-YL]ETHYL]PROPANAMIDE 95.00%
  • 5MG
  • $ 495.32
Total 3 raw suppliers
Chemical Property of (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide Edit
Chemical Property:
  • Melting Point:144-146 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) 
  • Boiling Point:512.4±50.0 °C(Predicted) 
  • PKA:10.46±0.40(Predicted) 
  • Density:1.154±0.06 g/cm3(Predicted) 
  • Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere 
  • Solubility.:DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) 
Purity/Quality:

97% *data from raw suppliers

(S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Uses Intermediate in the production of Ramelteon.
Technology Process of (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide

There total 10 articles about (S)-N-[2-[2,3-Dihydro-6-hydroxy-7-(2-hydroxyethyl)-1H-inden-1-yl]ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 9 steps
1.1: NaH / tetrahydrofuran / 20 °C
1.2: tetrahydrofuran / 20 °C
2.1: H2; ethanolic NH3 / Raney-Co
3.1: Et3N / tetrahydrofuran / 0 °C
4.1: 86 percent / NaOAc; Br2 / 0 °C
5.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C
6.1: NaH / dimethylformamide / 0 °C
6.2: 96 percent / dimethylformamide / 0 °C
7.1: 80 percent / various solvent(s) / 200 - 205 °C
8.1: O3 / methanol / -78 °C
8.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C
9.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C
With ammonia; hydrogen; bromine; sodium acetate; boron tribromide; sodium hydride; ozone; triethylamine; Raney-Co; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Horner-Emmons reaction / 7.1: Claisen rearrangement;
DOI:10.1021/jm0201159
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