[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester
CAS No.:748781-26-2
Molecular Formula:C₂₉H₄₁NO₆
Molecular Weight:499.648
Hs Code.:

[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

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Chemical Property of [1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

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Technology Process of [1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

There total 1 articles about [1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 152500-21-5
(S)-5-benzyloxymetyl-1-tert-butoxycarbonyl-2-pyrrolidinone

: 4-(p-methoxybenzyl)oxybutylmagnesium bromide

: 748781-26-2
[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.tetlet.2004.05.142

Reference yield: 87.0%

: 748781-26-2
[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

: 748781-27-3
4-(5-benzyloxymethyl-4,5-dihydro-3H-pyrrol-2-yl)-butan-1-ol

Guidance literature:: [1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

With sodium hydroxide; at 0 ℃; Further stages.;
DOI:10.1016/j.tetlet.2004.05.142

Reference yield:

: 748781-26-2
[1-benzyloxymethyl-8-(4-methoxy-benzyloxy)-4-oxo-octyl]-carbamic acid tert-butyl ester

: 844698-97-1
(3S,5R,7aS,11aS)-3-[(benzyloxy)methyl]-5-hexyloctahydro-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: TFA / CH₂Cl₂ / 0 - 20 °C

1.2: 87 percent / NaOH / 0 °C

2.1: 79 percent / DMAP; TEA / CH₂Cl₂

3.1: 74 percent / BF₃Et₂₀ / tetrahydrofuran / -78 °C

4.1: 90 percent / Na₂CO₃ / benzene / 20 °C

5.1: 96 percent / Bu₄NF / tetrahydrofuran / 20 °C

6.1: 93 percent / pyridine / 20 °C

7.1: 85 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 20 °C

8.1: pyrrolidine / toluene / Heating

8.2: 60 percent / ag. AcOH / 20 °C

9.1: tetrahydrofuran / 0 °C

10.1: 91 percent / MnO₂ / CH₂Cl₂ / 20 °C

11.1: 99 percent / H₂ / Lindlar catalyst / toluene / 20 °C

12.1: TFA / CH₂Cl₂ / 0 °C

12.2: 81 percent / ag. NaHCO₃ / 20 °C

With pyrrolidine; pyridine; dmap; manganese(IV) oxide; sodium periodate; osmium(VIII) oxide; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; trifluoroacetic acid; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; water; toluene; benzene; 3.1: Grignard reaction / 9.1: Grignard reaction / 12.2: intramolecular Michael addition;
DOI:10.1016/j.tetlet.2004.05.142