{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

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Chemical Name:{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester
CAS No.:208587-14-8
Molecular Formula:C₄₂H₅₄N₈O₁₀
Molecular Weight:830.938
Hs Code.:

{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

Synonyms:{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

There total 7 articles about {(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1027508-26-4
[2-(5-{[(S)-1-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyl)-pyrrolidine-2-carbonyl]-amino}-2-phenoxymethyl-benzoylamino)-acetylamino]-acetic acid ethyl ester

: 208587-14-8
{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrazine hydrate; In methanol; for 24h; Ambient temperature;
DOI:10.1021/jm970640l

Reference yield:

: 129229-78-3
2-phenoxymethyl-5-nitrobenzoic acid

: 208587-14-8
{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1,) DCC, HOBt / 1.) CH₂Cl₂, THF, 0 deg C, 15 min, 2.) CH₂Cl₂, THF, a) 0 deg C, 1 h, b) RT, 24 h

2: H₂ / PtO₂ / dimethylformamide; methanol / 2 h / Ambient temperature

3: HOBt, DCC / CH₂Cl₂; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

4: TFA / CH₂Cl₂ / 1.5 h / 0 °C

5: DCC, HOBt / CH₂Cl₂; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

6: 70 percent / NH₂NH₂*H₂O / methanol / 24 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970640l

Reference yield:

: [2-(5-Nitro-2-phenoxymethyl-benzoylamino)-acetylamino]-acetic acid ethyl ester

: 208587-14-8
{(S)-5-Benzyloxycarbonylamino-6-[(S)-2-(3-{[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-4-phenoxymethyl-phenylcarbamoyl)-pyrrolidin-1-yl]-6-oxo-hexyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / PtO₂ / dimethylformamide; methanol / 2 h / Ambient temperature

2: HOBt, DCC / CH₂Cl₂; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

3: TFA / CH₂Cl₂ / 1.5 h / 0 °C

4: DCC, HOBt / CH₂Cl₂; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, overnight

5: 70 percent / NH₂NH₂*H₂O / methanol / 24 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970640l