N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

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Chemical Name:N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine
CAS No.:858103-29-4
Molecular Formula:C₃₆H₃₉F₂N₃O₇S
Molecular Weight:695.784
Hs Code.:

Synonyms:N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

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Chemical Property of N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

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Technology Process of N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

There total 9 articles about N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: [2-(4-{(2R,3R)-1-(4-fluoro-phenyl)-3-[(RS)-2-(4-fluoro-phenyl)-2-hydroxy-ethylsulfanyl]-4-oxo-azetidin-2-yl}-phenoxy)-acetylamino]-acetic acid

: 58717-02-5
3-cyclohexyl-D-alanine

: 858103-29-4
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

Guidance literature:: [2-(4-{(2R,3R)-1-(4-fluoro-phenyl)-3-[(RS)-2-(4-fluoro-phenyl)-2-hydroxy-ethylsulfanyl]-4-oxo-azetidin-2-yl}-phenoxy)-acetylamino]-acetic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 1h;

3-cyclohexyl-D-alanine; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 0.5h;

Reference yield:

: C₃₆H₃₇F₂N₃O₇S

: 858103-29-4
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

Guidance literature:: C₃₆H₃₇F₂N₃O₇S; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.166667h;

With acetic acid; In methanol;

Reference yield:

: 858104-44-6
tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate

: 858103-29-4
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}glycyl-3-cyclohexyl-D-alanine

Guidance literature:: Multi-step reaction with 9 steps

1.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.08 h / 0 °C

1.2: 0.33 h / -40 - 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C

2.2: 18 h / 45 °C

2.3: 6 h / 45 °C

3.1: dichloromethane / 2 h / 0 °C

4.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

6.1: 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C

6.2: 25 h

7.1: trifluoroacetic acid / dichloromethane / 1 h

8.1: 4-methyl-morpholine; (1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / DMF (N,N-dimethyl-formamide) / 0.25 h / 20 °C

8.2: 20 °C

9.1: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

With 4-methyl-morpholine; titanium(IV) isopropylate; sodium tetrahydroborate; (1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; tributylphosphine; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; trifluoroacetic acid; In methanol; DMF (N,N-dimethyl-formamide); dichloromethane; acetone; toluene;