ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Base Information

Chemical Name:ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate
CAS No.:1609166-00-8
Molecular Formula:C₁₈H₁₅F₃N₂O₃
Molecular Weight:364.324
Hs Code.:

Synonyms:ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

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Chemical Property of ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

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Technology Process of ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

There total 3 articles about ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609166-33-7
4-fluoropyridin-3-ol hydrochloride

: 1609166-00-8
ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 50 °C

4: ethanol / 48 h / Inert atmosphere; Molecular sieve; Reflux

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; caesium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1609165-98-1
4-fluoro-2-nitropyridin-3-ol

: 1609166-00-8
ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 50 °C

3: ethanol / 48 h / Inert atmosphere; Molecular sieve; Reflux

With palladium 10% on activated carbon; hydrogen; caesium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1003710-90-4
2-amino-4-fluoropyridin-3-ol

: 1609166-00-8
ethyl 8-[(2,6-difluorobenzyl)oxy]-7-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 50 °C

2: ethanol / 48 h / Inert atmosphere; Molecular sieve; Reflux

With caesium carbonate; In ethanol; N,N-dimethyl-formamide;