(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

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Chemical Name:(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide
CAS No.:908140-21-6
Molecular Formula:C₄₀H₄₇N₅O₈S₃
Molecular Weight:822.04
Hs Code.:

(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

Synonyms:(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

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Chemical Property of (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

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Technology Process of (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

There total 7 articles about (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid

: N-[4-(1-amino-2-benzothiazol-2-yl-2-oxo-ethyl)-cyclohexyl]-4-methoxy-2,3,6-trimethyl-benzenesulfonamide; hydrochloride

: 908140-21-6
(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00636-3

Reference yield:

: 95-16-9
1,3-Benzothiazole

: 908140-21-6
(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi / tetrahydrofuran / -40 °C

2: 100 percent / 4.0 M HCl / dioxane

3: 78 percent / HATU; NMM / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00636-3

Reference yield:

: 336870-02-1
(S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid

: 908140-21-6
(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / DIEA; BOP / dimethylformamide

2.1: 73 percent / TPAP; N-methylmorpholine N-oxide; molecular sieves 4A / CH₂Cl₂

3.1: ammonium acetate; NaCNBH₃; molecular sieves 4 Angstroem / propan-2-ol

3.2: 38 percent / DMAP; DIEA / CH₂Cl₂

4.1: n-BuLi / tetrahydrofuran / -40 °C

5.1: 100 percent / 4.0 M HCl / dioxane

6.1: 78 percent / HATU; NMM / dimethylformamide

With 4-methyl-morpholine; ammonium acetate; hydrogenchloride; n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0960-894X(00)00636-3