N-formyl-o-thiophenetidine

Base Information

• Chemical Name: N-formyl-o-thiophenetidine
• CAS No.: 108429-58-9
• Molecular Formula: C₉H₁₁NOS
• Molecular Weight: 181.258
• Mol file: 108429-58-9.mol

Synonyms:N-formyl-o-thiophenetidine

Chemical Property of N-formyl-o-thiophenetidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-formyl-o-thiophenetidine

There total 4 articles about N-formyl-o-thiophenetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-(o-ethylthiophenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole (108429-54-5) → 2-(ethylthio)aniline (13920-91-7) + N-formyl-o-thiophenetidine (108429-58-9)

Guidance literature:

With Lithium enolate of the acetaldehyde; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/S0040-4020(01)87546-3

Reference yield:

2-amino-benzenethiol (137-07-5) → N-formyl-o-thiophenetidine (108429-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / ethanol / 0.75 h / Cooling with ice; Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; In ethanol; dichloromethane;

DOI:10.1021/acs.orglett.9b02837

Reference yield:

2-(ethylthio)aniline (13920-91-7) + formyl acetic anhydride (2258-42-6) → N-formyl-o-thiophenetidine (108429-58-9)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02837

upstream raw materials:

1-(o-ethylthiophenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole

1-azido-2-ethylsulfanylbenzene

2-(ethylthio)aniline

formyl acetic anhydride