N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

Base Information

Chemical Name:N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate
CAS No.:1345983-28-9
Molecular Formula:C₂HF₃O₂*C₂₇H₃₈N₂O₅S
Molecular Weight:616.699
Hs Code.:

Synonyms:N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

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Chemical Property of N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

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Technology Process of N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

There total 20 articles about N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.8%

: 1345984-21-5
1,1-dimethylethyl N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycinate

: 76-05-1
trifluoroacetic acid

: 1345983-28-9
N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

Guidance literature:: 1,1-dimethylethyl N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycinate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃; for 15h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 616-06-8
2-amino-hexanoic acid

: 1345983-28-9
N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

Guidance literature:: Multi-step reaction with 15 steps

1.1: thionyl chloride / 0 - 65 °C

2.1: magnesium sulfate; triethylamine / dichloromethane / 2 h / 25 °C

2.2: 0.5 h

2.3: 60 h / 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 25 °C

3.2: 20 h / 25 °C

4.1: hydrogenchloride; water / 0.5 h / 25 °C

4.2: 0 °C / pH 12

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 65 °C

5.2: 2 h / 0 °C

6.1: chlorosulfonic acid / ethyl acetate / 3 h / 25 - 40 °C

7.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

7.2: 15 h / 85 °C

8.1: citric acid / toluene / 50 h / 130 °C / Reflux

9.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

10.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

10.2: 0.5 h

11.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

12.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C

12.2: 1 h / pH 12 / Cooling with ice

13.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

14.1: acetic acid / 1,2-dichloro-ethane / 1 h / 25 °C

14.2: 9 h / 25 °C

15.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 15 h / 25 °C

With hydrogenchloride; chlorosulfonic acid; lithium aluminium tetrahydride; thionyl chloride; borane-THF; 1,3-bis-(diphenylphosphino)propane; water; dihydrogen peroxide; sodium hydride; magnesium sulfate; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 393855-85-1
2-amino-2-butylhexanyl hydrogen sulfate

: 1345983-28-9
N-{[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}glycine trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

1.2: 15 h / 85 °C

2.1: citric acid / toluene / 50 h / 130 °C / Reflux

3.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

4.2: 0.5 h

5.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

6.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C

6.2: 1 h / pH 12 / Cooling with ice

7.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

8.1: acetic acid / 1,2-dichloro-ethane / 1 h / 25 °C

8.2: 9 h / 25 °C

9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 15 h / 25 °C

With hydrogenchloride; lithium aluminium tetrahydride; borane-THF; 1,3-bis-(diphenylphosphino)propane; dihydrogen peroxide; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;