1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Base Information

• Chemical Name: 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate
• CAS No.: 1209008-29-6
• Molecular Formula: C₃₀H₃₆F₃N₅O₄S
• Molecular Weight: 619.708
• Mol file: 1209008-29-6.mol

Synonyms:1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Chemical Property of 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

There total 8 articles about 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridine-3-carboxylic acid (1209007-35-1) + 1,1,1-trifluoro-2-methylpropan-2-yl 4-(piperazin-1-yl)piperidine-1-carboxylate (1209008-04-7) → 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate (1209008-29-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 20h;

DOI:10.1016/j.bmc.2011.01.041

Reference yield:

1,1,1-trifluoro-2-methylpropan-2-yl 4-oxopiperidine-1-carboxylate (1209008-02-5) → 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate (1209008-29-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloroform / 1.5 h / 20 °C

1.2: 5 h

2.1: hydrogenchloride / ethyl acetate / 5 h

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.01.041

Reference yield:

imidazole-1-carboxylic acid 2,2,2-trifluoro-1,1-dimethyl-ethyl ester → 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-c]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate (1209008-29-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetonitrile / 32 h / 20 °C

2.1: triethylamine / chloroform / 2 h / 0 - 20 °C

3.1: chloroform / 1.5 h / 20 °C

3.2: 5 h

4.1: hydrogenchloride / ethyl acetate / 5 h

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmc.2011.01.041

upstream raw materials:

C₁₈H₁₈N₂O₃S

3-methyl-1-{[(1,1,1-trifluoro-2-methylpropan-2-yl)oxy]-carbonyl}-1H-imidazol-3-ium iodide

1,1,1-trifluoro-2-methylpropan-2-yl 4-oxopiperidine-1-carboxylate

tert-butyl 4-(1-{[(1,1,1-trifluoro-2-methylpropan-2-yl)oxy]carbonyl}piperidin-4-yl)piperazine-1-carboxylate