tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

Base Information

Chemical Name:tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate
CAS No.:438630-87-6
Molecular Formula:C₂₀H₃₄N₄O₄
Molecular Weight:394.514
Hs Code.:

Synonyms:tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

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Chemical Property of tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

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Technology Process of tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

There total 4 articles about tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 944475-09-6
tert-butyl (3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate

: 74124-79-1
di(succinimido) carbonate

: 438630-87-6
tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

Guidance literature:: tert-butyl (3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate; di(succinimido) carbonate; In acetonitrile; at 20 ℃; for 4.5h;

With ammonia; In 1,4-dioxane; acetonitrile; at 20 ℃; for 18h; Further stages.;
DOI:10.1021/jm061010z

Reference yield: 73.0%

: 438630-87-6
tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

Guidance literature:

Reference yield:

: 348622-98-0
ethyl 5-{(1R)-1-[2-(tert-butoxy)-2-oxoethyl]-4-cyclohexylbutyl)-1,2,4-oxadiazole-3-carboxylate

: 438630-87-6
tert-butyl (3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexylhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaBH₄

2.1: 94 percent / NH₃ / tetrahydrofuran / 18 h / 50 °C

3.1: acetonitrile / 4.5 h / 20 °C

3.2: 73 percent / NH₃ / dioxane; acetonitrile / 18 h / 20 °C

With sodium tetrahydroborate; ammonia; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm061010z